Toyota's first-generation Sienna is refined, but the third-row accommodations are snug. In 2003 a redesigned Sienna went on sale. It is roomier and more powerful, and it's available with AWD. Reliability has been very good overall. The Honda Odyssey isn't as plush but has better handling.
These have multiple years of much-worse-than-average reliability among 1999 to 2008 models. Listed alphabetically.
Audi A6 Allroad
Audi A8
BMW X5 (V8 )
Buick Rendezvous (AWD)
Cadillac SRX
Chevrolet Blazer
Chevrolet Colorado (4WD)
Chevrolet S-10 (4WD)
Chevrolet Uplander
Chevrolet Venture
Chrysler Pacifica
Chrysler Sebring convertible
Chrysler Town & Country (AWD)
Dodge Grand Caravan (AWD)
GMC Canyon (4WD)
GMC Jimmy